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At Dermo Direct, we are frequently asked: âWhat supplements can I take while on isotretinoin?â âAre there vitamins that help with dryness or side effects?â âWhich supplements should I avoid?â As a Dermatologist â I often suggest that a lot of oral supplements are not needed whilst taking isotretinoin, as gentle skin care, emollient use and sunscreen/sun protection are the key focus areas for patients taking isotretinoin â but if patients are struggling with certain side effects, some of the following supplements can help