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Trial dose range: 1–12mg, once weekly, subcutaneous Standard escalation: 2mg → +2mg every 4 weeks → 12mg (~20 weeks) Pharmacokinetics: half-life ~6 days

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Western blot analysis illustrated that sulforaphane increased the expression of nuclear factor (erythroid-derived 2)-like 2 (Nrf2), heme oxygenase-1 (HO-1) and NAD(P)H quinone oxidoreductase (NQO1), the latter two of which are anti-oxidative enzymes