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In patients with T2DM who do not have atherosclerotic cardiovascular disease (ASCVD)/indicators of high-risk, HF, or CKD and who need to minimize hypoglycemia and/or promote weight loss, GLP-1 RAs are generally recommended as a second or third-line option as add-on to metformin therapy

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2.3 Semen collection Semen was collected from six bucks twice weekly for five weeks using an artificial vagina, one week prior to the formal experiment, semen collection was similarly performed to eliminate dead sperm