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Dose-dependent benefits of γ-tocotrienol were observed in the BALF of mice exposed to CS for 2 weeks, reducing neutrophil counts and levels of cytokines, chemokines, and oxidative damage biomarkers, as well as pulmonary pro-inflammatory and pro-oxidant gene expression, and restoring lung endogenous antioxidant activities, as indicated by inhibition of nuclear translocation of signal transducer and activator of transcription 3 (STAT3) and NF-κB, and upregulation of Nrf2