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[43a] Taken together, the molecular consequences of MBR and WTL SOD1 mutations appear to merge into a single unifying theme underlying SOD1 protein misfolding: mutations not only disrupt SOD1 maturation to promote the accumulation of disordered immature SOD1 conformers, but may substantially accentuate structural instability within already disordered microenvironments in apo‐SOD1
