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The neurotoxic effects of excessive glutamate include the overactivation of both ionotropic and metabotropic glutamate receptors, which leads to a substantial influx of Ca 2+ into cells, resulting in apoptosis and necrosis (Lai et al., 2014)
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Hyperalgesia (an exaggerated response to a normally painful stimulus) and allodynia (pain from a nonpainful stimulus such as light touch) are direct clinical manifestations of this heightened gain throughout the somatosensory system
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