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The N-terminal domain of the target-binding site has two residues, Glu 5 and Glu 9, that are the most highly conserved in S100 proteins (136)
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A Balanced Act of Mitochondrial Biogenesis and Mitophagy Mitochondrial function is multifaceted in response to cellular energy homeostasis and metabolism, including calcium homeostasis, amino acid metabolism, pyridine synthesis, cellular replication, apoptosis, reactive oxygen species (ROS) production, and senescence (Spinelli and Haigis, 2018)