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Reduced ability of HDL to stimulate NO production from endothelial cells and decreased vasorelaxation properties are reported for T2DM (887,888), T1DM (889), mild chronic kidney disease (CKD) (890), and rare forms of autoimmunity (ALPS) (891)

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Brain In the transient mouse middle cerebral artery occlusion (MCAO) model, liproxstatin-1 treatment commencing at the time of early reperfusion markedly attenuated MCAO-induced functional deficits, improved the neuroscore and reduced infarct volumes, suggesting a direct involvement of ferroptosis in ischemic stroke [502]