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While ammonium accumulation-mediated acidification has been experimentally validated ( in vitro and in vivo ) to drive immunosuppression in the prostate cancer TME, primarily through impairing T cell and NK cell cytotoxicity and promoting M2 macrophage polarization
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cerevisae , which can run transsulfuration in either direction, has two sets of transsulfuration enzymes – one for the Hcy → Cys direction and one for the Cys → Hcy direction – thereby further emphasizing the dedicated directionality of the enzymes on the pathway [121, 136]
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