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Mice with ghr Box1 deletion by substitution of each proline in the Box1 to alanine (which eliminates JAK2 binding and signaling, while still allowing signaling to occur via the SFK–ERK1/2 pathway) have obstructed growth with a similar phenotype observed in mice with ghr KO (109, 110)

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Kefiran, an exopolysaccharide derived from the microflora of kefir, has garnered significant attention from researchers due to its diverse biological properties, biocompatibility, and versatile applications, ranging from nanomedicine to food packaging