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GLP-1 and amylin both converge on hypothalamic appetite circuits and brainstem nausea pathways Additive effects on satiety often produce additive nausea and gastrointestinal adverse events, which can exceed the tolerability threshold even if the weight-loss effect is favorable Drug-drug pharmacokinetic interactions are not predictable from receptor logic alone The dose-response curves of each drug were established in monotherapy

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10.1016/j.redox.2017.07.007 Redox Biol