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Say the patient was going on holiday on the Monday, then why would giving the patient it a day early (from a day they are not open) be any strain on resources as the patient is not going to book another appointment on the Monday

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HGF Induces Angiogenesis in the Nervous System The ischemic stroke caused by reduced blood supply to specific areas of the brain leads not only to neuronal death but also to endothelial cell damage, which can result in the disruption of the BBB