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Objective physiological data gathered from skin biopsies in this same study showed that after approximately six months of targeted supplementation with L-methylfolate, methylcobalamin, and pyridoxal 5'-phosphate, 73% of the patients demonstrated a measurable increase in calf epidermal nerve fiber density

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This oxidative damage happens as a result of conditions, such as thalassemia and other hemoglobinopathies [6]

In a permeability study