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Heinrich determined that a dose (D) of cyanocobalamin is absorbed at a rate of: Stephen Walsh, PhD, a mathematical modeler associated with the UK Vegan Society, has analyzed Heinrich’s data and found this formula to be a better fit: Heinrich’s data assumes that the cyanocobalamin is taken on an empty stomach

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When variants of uncertain significance are identified, in vitro flux studies or measurement of enzyme activities are necessary to provide definitive diagnosis