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489 Another role of mTOR has been identified through its connection with endonuclease G, which promotes NAFLD via mTORC2 upregulation and ER stress
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At the same time, reduced IDO activity reduced kynurenine and further weakened peripheral immune tolerance, which played a driving role in the hypothyroidism immune disorder caused by the imbalance of the whole gut microbiota (Clarke et al., 2017)
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