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In vivo, plasma half-life has been measured at 7–8 minutes — suggesting that in the body, DSIP may complex with carrier proteins that protect it from rapid degradation, or exist as a component of a larger precursor molecule (whose gene and structure have not yet been identified)
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It was shown that GHR interacts with Lyn (an SFK), and that a deficiency in Lyn activation was responsible for the impaired ERK1/2 activation (109)
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