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While this treatment was considered safe after various phase I clinical trials (NCT00879749, NCT02528799 and NCT03543540) [114,115,116], a phase 2 study (NCT03644069) [117] concluded that after administration of escalating doses (from 1 µg to 750 µg for 5 weeks and then 900 µg for 11 weeks), Nexvax2 was not capable of reducing the symptoms associated with gluten consumption in CeD in a posterior 10 g gluten challenge at week 14
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