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Similarly, in the CCK2R–G q complex, the last seven amino acids of the G q -α5 helix extensively interacts with V88 2.38 and T89 2.39 of TM2, R152 3.50 , A155 3.53 , and I156 3.54 of TM3, Q166 ICL2 at ICL2, L245 5.65 of TM5, V331 6.33 and L335 6.37 of TM6, and H394 8.47 at the TM7–Helix8 hinge in CCK2R (Fig