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This molecule has several effects on the expression of the gene[] which finally leads to an increase in the production of deleterious products and reduces the production of needed products in the normal functioning of the cells, for example, reduction in the synthesis of endothelial nitric oxide and increase in production of vasoconstrictor endothelin-1[]
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Prior to the LDopa/carbidopa intestinal gel (LCIG) era, subclinical or clinical mild PN was observed in up to 50% of PD patients receiving oral LDopa
