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Common side effects include: PML Increased risk of infections Infusion reactions Headaches Fatigue Gastrointestinal issues Liver damage Alemtuzumab (Lemtrada) Secondary autoimmune conditions such as Graves' disease and immune thrombocytopenia Cancers such as thyroid cancer and melanoma Hyperthyroidism and hypothyroidism (overactive and underactive thyroid, respectively) Bone marrow issues Stroke Infusion reactions Kidney problems Serious infections Bleeding disorders such as hemophilia Swelling or inflammation of the colon, liver, gallbladder, and lung tissue Multifocal leukoencephalopathy (PML) Mitoxantrone (Novantrone) What to Expect During Infusion Therapy Understanding what to expect from an infusion therapy appointment and taking steps to prepare for it may reduce any stress or anxiety you may feel about the treatment