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In a recent study, the treatment with a HDAC inhibitor in mice subjected to cerebral ischemia leads to an enhanced expression of the TJ proteins ZO-1, Occludin, and Claudin-5 in brain endothelial cells, further decreasing the BBB permeability (Su et al., 2020)
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A 4 de agosto, la página de riesgos de compounding de la FDA seguía señalando problemas de inmunogenicidad, agregados, impurezas y ausencia de información humana suficiente