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doi: 10.1093/nar/gky962

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For B6, you might notice symptoms like: Depression Confusion Weakened immune function Cracks at the corners of your mouth A swollen tongue With B12 deficiency, signs may include: Fatigue Weakness Pale or jaundiced skin (yellow skin) Cognitive difficulties Mood changes Nerve damage, which may cause numbness or tingling in your hands and feet It’s also worth noting that deficiencies in either vitamin can lead to anemia, though they manifest in different ways