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Note that antidepressive behaviors at 1 h after ketamine treatment was not affected by adult NPCs-specific TrkB deletion, suggesting that the sustained antidepressive effect of ketamine depends on BDNF/TrkB-mediated neurogenesis while rapid antidepressive effect is occurred through neurogenesis-independent BDNF/TrkB action [65]
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Requirements of vitamin B 12 in excess of normal (due to pregnancy, thyrotoxicosis, hemolytic anemia, hemorrhage, malignancy, hepatic and renal disease) can usually be met with intranasal or oral supplementation
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