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Nuclear-localized PKM2 co-activates HIF1α the aerobic glycolysis regulator to reshape a metabolic landscape that favors glucose anabolic fate towards lipid biogenesis Our data so far revealed that in the absence of ATM, insulin-sensitive cells fail to translate the hormonal signal into an instantaneous metabolic transition that fosters anabolic reactions that are particularly important for general growth and development during early childhood to early puberty 84

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