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According to Kannt & Pfenninger in Frontiers in Physiology , NAD⁺ is a critical coenzyme in mitochondrial energy metabolism, and strategies that preserve NAD⁺ have wide-ranging effects on health and performance (Kannt & Pfenninger, Frontiers in Physiology )
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This distinction gets emphasized throughout peptide research literature for good reason: mechanical agitation from shaking can physically disrupt the bonds holding a peptide’s amino acid chain together, a form of damage that can’t be reversed once it occurs
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