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They have included in two classes: the “caretakers” of the genome (or Type I), which are DNA repair genes that protect the genome from mutations (XPB, MSH2, etc.), and the gatekeepers (or Type II), which avert cancer through direct control of cell growth (p53, p16, etc.).The inactivation of tumor suppressor genes by loss or mutation is a vital step for the development of tumors [23]

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Currently, clinical studies are underway to investigate the use of ticagrelor in SCD treatment, reducing and contributing to complications such as VOCs and strokes, which have shown satisfactory tolerance and safety [59,60]