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When selenium is reduced, some selenoproteins in the body quickly disappear (low grades), while others can continue to be synthesized even when selenium levels are reduced (high grades) (Banning et al., 2008b)

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Through high-performance liquid chromatography-tandem mass spectrometry (LC-MS/MS)-based molecular weight identification, standard molecular weight comparison, and characteristic HPLC profiles of the [ 3 H]proline and [ 3 H]BPC157 standards (Supplementary Figure S2), we speculated the structures of these six components and designated them as M1–M6 (Table 10)