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Because SDH is the only enzyme that participates in both the TCA cycle and the ETC, we speculated that the ETC might be compromised in Gclc -deficient FoB, thus explaining the inhibition of SDH and the accumulation of succinate

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It consists of 11 exons at the 5′ end and is regulated by nine functional promoters, although the number of exons is 12 according to the National Library of Medicine (Gen ID) [5,13]