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Large numbers of phagocytic macrophages persist in the COI for over 4 weeks apparently sustained by a mechanism of a vicious cycle where damaged myelin is potently chemotactic and chemokines elevated, resulting in activation of infiltrating macrophages that coincides with additional damage to the surrounding CNS with damage to oligodendrocytes and myelin resulting in more macrophage chemotaxis [15, 16]

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Second, the ingredient carries prominent antioxidant potency to clear excess reactive oxygen species (ROS) accumulated inside cerebral tissue, curb oxidative injury targeting cerebellar granule neurons, and lower disruptive neuroinflammation that disturbs the normal function of brain sleep regulatory centers