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Mechanistically, the peptide perturbs the FOXO4 interaction with p53, which selectively causes p53 nuclear exclusion and cell-intrinsic apoptosis (Figure 2, this novel senolytic did remove cells from the PDL9 chondrocytes, which was accompanied by significantly reduced levels of SA-β-gal staining

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[DOI] [PubMed] [Google Scholar] 140.Sculean A, Chiantella GC, Windisch P, Arweiler NB, Brecx M, Gera I