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Several factors may hinder the absorption of natural food folate, e.g., partial release from the food matrix (incomplete liberation from cellular structures), destruction within the gastrointestinal tract, and incomplete hydrolysis of polyglutamates to monoglutamates (possibly mediated by partial inhibition of deconjugation enzymes by other dietary constituents such as organic acids)

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These allergic responses can be modest, affecting only the cutaneous tissues, resulting in life-threatening anaphylaxis