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10 days for third-line eradication therapy Benign gastric ulceration ▶ ▶ BY MOUTH ▶ BY INTRAVENOUS INFUSION Adult: 20 mg once daily for 8 weeks, increased if necessary to 40 mg once daily, in severe or recurrent cases Duodenal ulceration Adult: 40 mg once daily until oral administration possible, infusion to be given over 20–30 minutes Major peptic ulcer bleeding (following endoscopic treatment) ▶ ▶ ▶ BY MOUTH ▶ INITIALLY BY INTRAVENOUS INFUSION Adult: 20 mg once daily for 4 weeks, increased if necessary to 40 mg once daily, in severe or recurrent cases Prevention of relapse in gastric ulcer ▶ ▶ Adult: Initially 80 mg, to be given over 40–60 minutes, then (by continuous intravenous infusion) 8 mg/hour for 72 hours, subsequent dose then changed to oral therapy ▶ BY MOUTH Adult: 20 mg once daily, increased if necessary to 40 mg once daily Prevention of relapse in duodenal ulcer ▶ ▶ BY MOUTH Adult: 20 mg once daily, dose may range between 10–40 mg daily NSAID-associated duodenal ulcer | NSAID-associated gastric ulcer | NSAID-associated gastroduodenal erosions ▶ ▶ BY MOUTH Adult: 20 mg once daily for 4 weeks, continued for a further 4 weeks if not fully healed Prophylaxis in patients with a history of NSAID-associated duodenal ulcer who require continued NSAID treatment | Prophylaxis in patients with a history of NSAIDassociated gastric ulcer who require continued NSAID treatment | Prophylaxis in patients with a history of NSAID-associated gastroduodenal lesions who require continued NSAID treatment | Prophylaxis in patients with a history of NSAID-associated dyspeptic symptoms who require continued NSAID treatment ▶ ▶ BY MOUTH Adult: 20 mg once daily Zollinger–Ellison syndrome ▶ ▶ BY MOUTH ▶ Adult: Initially 60 mg once daily

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The aforementioned literature emphasizes the critical interrelationships between folate and vitamin B12 in maintaining central nervous system function and protecting against cognitive decline