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This point is an irreversible commitment to a new division cycle at the end of G1 ( CLN1 and CLN2 ( CLB5 and CLB6 that can initiate DNA synthesis ( Metabolic signaling through both the protein kinase A (PKA) pathway and the target of rapamycin (TOR) pathway constitutes the bridges between the nutrient status and START (Figure 1)
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Example of linker cleaved by cathepsin B Figure 6
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