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In preclinical animal models: wound closure accelerated (50% closure day 5 vs vehicle day 7, full-thickness excisional model), tendon tensile strength improved (+58% at day 14 vs vehicle, Achilles model), gastric lesion index reduced (−68–78% vs vehicle, ethanol ulcer model), inflammatory cytokines reduced (TNF-α −42–52%, IL-6 −38–44%, colitis model), angiogenesis stimulated (CD31+ MVD +44% vs vehicle), and neuroprotection demonstrated (NSS improved, lesion volume −28–34%, TBI model)