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While mitochondrial ROS generation may be important for regulation of mitochondrial uncoupling protein (UCP) activity and thus disruption of cellular energy metabolism, the NADPH oxidase associated ROS may alter parameters of signal transduction, insulin secretion, insulin action and cell proliferation or cell death

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Some algae and plants have an NADPH-independent thioredoxin reductase that, instead, obtains reducing power directly from the electron transport chain of the photosynthesis light-reaction